Journal: European Journal of Neurology
Authors: Rebecca Persson, Sally Lee, Marianne Ulcickas-Yood, Michael R Wagner, Neil Minton, Steve Niemcryk, Anders Lindholm, Amber M Evans, Susan S Jick
NLM Citation: Persson R, Lee S, Yood MU, Wagner MR, Minton N, Niemcryk S, Lindholm A, Evans AM, Jick S. Incident depression in patients diagnosed with multiple sclerosis: a multi-database study. Eur J Neurol. 2020 Aug;27(8):1556-1560. doi: 10.1111/ene.14314. Epub 2020 Jun 8. PMID: 32397001.
Abstract
Background and purpose: Data on rates of newly diagnosed depression after multiple sclerosis (MS) diagnosis are sparse. Here, incident, treated depression in MS patients after diagnosis compared with matched non-MS patients is described.
Methods: A matched cohort study was conducted in two separate electronic medical databases: the US Department of Defense (US-DOD) military healthcare system and the UK’s Clinical Practice Research Datalink GOLD (UK-CPRD). The study population included all patients with a first recorded diagnosis of MS and matched non-MS patients. Patients with a history of treated depression were excluded. Incidence rates and incidence rate ratios with 95% confidence intervals for treated depression after MS diagnosis/matched date were estimated.
Results: Incidence rate ratios of treated depression amongst MS patients compared with non-MS patients were 3.20 (95% confidence interval 3.05-3.35) in the US-DOD and 1.90 (95% confidence interval 1.74-2.06) in the UK-CPRD. Incidence rate ratios were elevated across age and sex. Rates were higher in females than males but, compared to non-MS patients, males with MS had a higher relative risk than females with MS.
Conclusions: Multiple sclerosis patients in the UK and the USA have a two- to three-fold increased risk of new, treated depression compared to matched non-MS patients.
Keywords: depression; epidemiology; incidence; multiple sclerosis.
© 2020 European Academy of Neurology.
