Boston Collaborative Drug Surveillance Program

By: Jeff | August 11, 2016

Authors: Yang C, Jick SS, Jick H.
Published in: Br J Clin Pharmacol 2002;53:101-105
Abstract 27:

DID: 27
Authors: Yang C, Jick SS, Jick H.
Title: Br J Clin Pharmacol 2002;53:101-105
Reference: Statins and the risk of idiopathic venous thromboembolism
No direct link.

Abstract:
Aims: To evaluate the association between current statin use and the risk of idiopathic venous thromboembolism (VTE). Methods: A population-based retrospective follow-up with a nested case-control analysis using the General Practice Research Database. Results: There were 72 cases of idiopathic VTE. Using normolipidemic nonuse as the reference group, the adjusted relative risks for idiopathic VTE for current/recent statin use, past statin use, past other lipid-lowering drug use,...

By: Jeff | August 11, 2016

Authors: Kaye JA, Meier CR, Walker AM, Jick H.
Published in: Br J Cancer 2002;86:1436-1439
Abstract 28:

DID: 28
Authors: Kaye JA, Meier CR, Walker AM, Jick H.
Title: Br J Cancer 2002;86:1436-1439
Reference: Statin use, hyperlipidemia, and the risk of breast cancer
No direct link.

Abstract:
Hydroxymethyl glutaryl coenzyme A inhibitors (‘statins’) are carcinogenic in rodents and an increased incidence of breast cancer was reported among pravastin users in one randomized trial. We conducted a case-control study in the General Practice Research Database (GPRD) to evaluate the risk of breast cancer among 50- to 79-year-old women treated with statins for hyperlipidemia. Case and control women were matched by age, general practice, duration of prescription...

Category: Publications 2002 

Tags: Br J Cancer 

By: Jeff | August 11, 2016

Authors: Meier CR, Schmitz S, Jick H.
Published in: Pharmacotherapy 2002;22:303-309
Abstract 29:

DID: 29
Authors: Meier CR, Schmitz S, Jick H.
Title: Pharmacotherapy 2002;22:303-309
Reference: Association between acetaminophen or nonsteroidal antiinflammatory drugs and risk of developing ovarian, breast, or colon cancer
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Abstract:
Study Objective: To explore the association between exposure to acetaminophen (paracetamol) or nonsteroidal antiinflammatory drugs (NSAIDs) and risk of developing ovarian, breast, or colon cancer. Design: Retrospective case-control study. Setting: General practice offices. Subjects: 483 women with ovarian cancer and 1,877 women matched for age, years of medical history in compute record, general practice att...

By: Jeff | August 11, 2016

Authors: Kornegay CJ, Vasilakis-Scaramozza C, Jick H.
Published in: J Clin Psychiatry 2002;63:758-762
Abstract 30:

DID: 30
Authors: Kornegay CJ, Vasilakis-Scaramozza C, Jick H.
Title: J Clin Psychiatry 2002;63:758-762
Reference: Incident diabetes associated with antipsychotic use in the United Kingdom General Practice Research Database
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Abstract:
This study evaluated the risk of incidence diabetes associated with the use of atypical and conventional antipsychotics. Method: This nested case-control study included all patients in the U.K. General Practice Research Database treated with antipsychotic drugs between January 1994 and December 1998. The main outcome measures were the odds ratios of current (within prior 6 months) or recent (...

By: Jeff | August 11, 2016

Authors: Black C, Kaye JA, Jick H.
Published in: Br J Clin Pharmacol 2002;53:637-640
Abstract 31:

DID: 31
Authors: Black C, Kaye JA, Jick H.
Title: Br J Clin Pharmacol 2002;53:637-640
Reference: Clinical risk factors for venous thromboembolus in users of the combined oral contraceptive pill
No direct link.

Abstract:
Aims: To estimate the risk of venous thromboembolism among women prescribed the oral contraceptive pill who have acute clinical conditions such as lower limb fractures, compared with women with idiopathic venous thromboembolism. Methods: A nested case-control analysis using the General Practice Research Database, January 1993 to December 1999 was carried out. The participants were women aged 15-39 years, prescribed third generation oral ...

By: Jeff | August 11, 2016

Authors: Meier CR, Krähenbühl S, Schlienger RG, Jick H.
Published in: J Hepatology 2002;37:741-747
Abstract 32:

DID: 32
Authors: Meier CR, Krähenbühl S, Schlienger RG, Jick H.
Title: J Hepatology 2002;37:741-747
Reference: Association between body mass index and liver disorders: an epidemiological study
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Abstract:
Aims: Cross-sectional studies showed an association between obesity and liver disorders. Information on incidence rates from epidemiological studies is scarce. Methods: To explore the association between body mass index (BMI) and incident liver disorders, we conducted a follow-up study with a nested case-control analysis using the UK-based General Practice Research Database. The study population encompassed normal weight (BM...

Category: Publications 2002 

Tags: J Hepatology 

By: Jeff | August 11, 2016

Authors: Schlienger RG, Jick H, Meier CR.
Published in: Br J Clin Pharmacol 2002;54:327-332
Abstract 33:

DID: 33
Authors: Schlienger RG, Jick H, Meier CR.
Title: Br J Clin Pharmacol 2002;54:327-332
Reference: Use of nonsteroidal anti-inflammatory drugs and the risk of first-time acute myocardial infarction
No direct link.

Abstract:
Aims: Aspirin decreases the risk of clinical manifestations of atherothrombosis. This effect is mainly due to inhibition of platelet aggregation and potentially due to anti-inflammatory properties of aspirin. To evaluate whether use of non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs) may also be associated with a decreased risk of first-time acute myocardial infarction (AMI), we performed a population-based case...

By: Jeff | August 11, 2016

Authors: Black C, Kaye JA, Jick H.
Published in: Br Med J 2002;325:419-421
Abstract 34:

DID: 34
Authors: Black C, Kaye JA, Jick H.
Title: Br Med J 2002;325:419-421
Reference: Relation of childhood gastrointestinal disorders to autism: nested case-control study using data from the UK General Practice Research Database
No direct link.

Abstract:
Objectives: To assess whether children with autism are more likely to have a history of gastrointestinal (GI) disorders than children without autism. Design: Nested case-control study. Setting: UK General Practice Research Database. Subjects: Children born after 1 January 1988 and registered with the General Practice Research Database within 6 months of birth. Outcome measures: Chronic inflammation of the GI tr...

Category: Publications 2002 

Tags: Brit Med J 

By: Jeff | August 11, 2016

Authors: Bradbury BD, Jick SS.
Published in: Pharmacotherapy 2002;22:697-700
Abstract 35:

DID: 35
Authors: Bradbury BD, Jick SS.
Title: Pharmacotherapy 2002;22:697-700
Reference: Itraconazole and fluconazole and certain rare, serious adverse events
No direct link.

Abstract:
Study Objective: To determine rates of drug-induced, rare, serious adverse events affecting the liver, kidneys, skin, or blood, occurring within 45 days of completing a prescription or refill for itraconazole or fluconazole. Design: Population-based follow-up study. Setting: United Kingdom-based General Practice Research Database. Patients: Total of 54,803 users of either fluconazole or itraconazole. Main results: Four patients were identified with illnesses for which a drug-indu...

By: Jeff | August 11, 2016

Authors: Black C, Jick H.
Published in: Pharmacotherapy 2002;22:1524-1526
Abstract 36:

DID: 36
Authors: Black C, Jick H.
Title: Pharmacotherapy 2002;22:1524-1526
Reference: Etiology and frequency of rhabdomyolysis
No direct link.

Abstract:
Study objectives: To describe the etiology and characteristics of patients with clinically diagnosed rhabdomyolysis in the United Kingdom General Practice Research Database (GPRD), and to estimate the risk of rhabdomyolysis in general and that associated with lipid-lowering agents in particular. Design: Retrospective analysis. Setting: The GPRD. Patients: A base population of patients aged 20-75 years. Intervention: Patients hospitalized with a computer-recorded code for acute myositis or myoglobinuria, or with ‘r...

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