Boston Collaborative Drug Surveillance Program

By: Jeff | October 20, 2016

Authors: Fischer LM, Schlienger RG, Matter C, Jick H, Meier CR.
Published in: Am J Cardiology 2004;93:198-200
Abstract 48:

DID: 48
Authors: Fischer LM, Schlienger RG, Matter C, Jick H, Meier CR.
Title: Am J Cardiology 2004;93:198-200
Reference: Effect of rheumatoid arthritis or systemic lupus erythematosus on the risk of first-time acute myocardial infarction
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Abstract:
We explored the association between diagnosed rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE) and the risk of developing a first-time acute myocardial infarction (AMI) by conducting a population-based, case-control analysis using data from the United Kingdom-based General Practice Research Database (GPRD). Among 8,688 patients with AMI and 33,329 matche...

By: Jeff | October 20, 2016

Authors: Peng MM, Jick H.
Published in: Arch Intern Med 2004;164:317-319
Abstract 49:

DID: 49
Authors: Peng MM, Jick H.
Title: Arch Intern Med 2004;164:317-319
Reference: A population-based study of the incidence, cause, and severity of anaphylaxis in the United Kingdom
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Abstract:
Background: Anaphylaxis is an acute and potentially fatal systemic reaction usually caused by mast cell-mediated release of histamine. Symptoms can vary in onset, appearance and severity. Some common symptoms include weakness, dizziness, flushing, angioedema, urticaria, nasal congestion and sneezing. Severe symptoms include upper respiratory tract obstruction, hypotension, vascular collapse associated with angioedema and urticaria, gastrointestinal distress,...

By: Jeff | October 20, 2016

Authors: Jick H, Kaye JA, Black C.
Published in: Br J Gen Practice 2004;54:345-347
Abstract 50:

DID: 50
Authors: Jick H, Kaye JA, Black C.
Title: Br J Gen Practice 2004;54:345-347
Reference: Incidence and prevalence of drug-treated attention deficit disorder among boys in the UK
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Abstract:
Background: Drug treatment for attention deficit disorder (ADD) was rare in the United Kingdom (UK) until in the mid-1990s. This contrasts with North America, where such treatment has been used to treat ADD for many decades. Since no quantitative data on the incidence and prevalence of drug-treated ADD are available in the UK, we used the General Practice Research Database (GPRD) to obtain such information. Aims: To provide estimates of incidence an...

By: Jeff | October 20, 2016

Authors: Schlienger RG, Jick SS, Meier CR.
Published in: Pediatrics 2004;114:469-473
Abstract 51

DID: 51
Authors: Schlienger RG, Jick SS, Meier CR.
Title: Pediatrics 2004;114:469-473
Reference: Inhaled corticosteroids and the risk of fractures in children and adolescents
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Abstract:
Objective: To determine whether children or adolescents who are exposed to inhaled corticosteroids (ie, beclomethasone, budesonide, fluticasone) are at a higher risk of having bone fractures compared with nonexposed individuals. Methods: We performed a population-based nested case-control analysis using data from the United Kingdom-based General Practice Research Database (GPRD). Within a base population of 273,456 individuals aged 5 to 79 years, we identif...

Category: Publications 2004 

Tags: Pediatrics 

By: Jeff | October 20, 2016

Authors: Meier CR, Wilcock K, Jick SS.
Published in: Drug Safety 2004;27:200-213
Abstract 52:

DID: 52
Authors: Meier CR, Wilcock K, Jick SS.
Title: Drug Safety 2004;27:200-213
Reference: The risk of severe depression, psychosis or panic attacks with prophylactic antimalarials
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Abstract:
Introduction/Objective: Experimental and observational studies have linked mefloquine use to an increased risk of developing neuropsychiatric adverse effects such as depression or psychoses. Most of these reports relied on interview-based information from travellers. We conducted a population-based observational study using a database of medical records to quantify and compare the risk of psychiatric disorders during or after use of mefloquine with the...

Category: Publications 2004 

Tags: drug Safety 

By: Jeff | October 20, 2016

Authors: Kaye JA, Jick H.
Published in: Brit J Cancer 2004;90:635-7.
Abstract 53:

DID: 53
Authors: Kaye JA, Jick H.
Title: Brit J Cancer 2004;90:635-7.
Reference: Statin use and cancer risk in the General Practice Research Database
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Abstract:
In a matched case–control study using the General Practice Research Database, current statin use was not associated with a significantly altered risk of any of 13 studied cancers. Untreated hyperlipidaemia was associated with slightly increased risks of colon cancer (relative risk 1.8; 95% confidence interval 1.2–2.8), prostate cancer (1.5; 1.1–2.0), and bladder cancer (1.9; 1.2–3.1).

By: Jeff | October 20, 2016

Authors: Miller DP, Kaye JA, Shea K, Ziyadeh N, Cali C, Black C, Walker AM.
Published in: Epidemiology 2004;15:208-215.
Abstract 54:

DID: 54
Authors: Miller DP, Kaye JA, Shea K, Ziyadeh N, Cali C, Black C, Walker AM.
Title: Epidemiology 2004;15:208-215.
Reference: Incidence of thrombotic thrombocytopenic purpura/hemolytic uremic syndrome
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Abstract:
Background: Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome are rare disorders characterized by platelet aggregation, microthrombi, and resulting tissue damage. We studied the incidence and possible risk factors for these diseases in 3 large populations in the United States, United Kingdom, and Canada. Methods: Data were derived from a large health insurer in the United St...

Category: Publications 2004 

Tags: Epidemiology 

By: Jeff | October 20, 2016

Authors: Jick SS, Bradbury BD.
Published in: Brit J Clin Pharmacol 2004;58:303-309.
Abstract 55:

DID: 55
Authors: Jick SS, Bradbury BD.
Title: Brit J Clin Pharmacol 2004;58:303-309.
Reference: Statins and newly diagnosed diabetes
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Abstract:
Aims In order to evaluate a hypothesized protective effect of the use of HMG Co-A reductase inhibitors (statins) on the development of Type 2 diabetes, we conducted a nested case–control study based on data from the UK-based General Practice Research Database (GPRD). Methods We identified a population of adults 30–79 years of age between 1 January 1991 and 31 March 2002, who were being treated with a statin or who were diagnosed with hyperlipidaemia but were not being treated with a lipid-lowering ...

By: Jeff | October 20, 2016

Authors: Jick H, Kaye JA, Jick SS.
Published in: JAMA 2004;292:338-343.
Abstract 56:

DID: 56
Authors: Jick H, Kaye JA, Jick SS.
Title: JAMA 2004;292:338-343.
Reference: Antidepressants and the risk of suicidal behaviors
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Abstract:
Context: The relation between use of antidepressants, especially selective serotonin reuptake inhibitors (SSRIs), and suicidal ideation and behaviors has received considerable public attention recently. The use of such drugs among teenagers has been of particular concern. Objective: To estimate the relative risks (RRs) of nonfatal suicidal behavior in patients starting treatment with 1 of 3 antidepressant drugs compared with patients starting treatment with dothiepin. DESIGN AND SETTING: Matched case-control...

Category: Publications 2004 

Tags: JAMA 

By: Jeff | October 20, 2016

Authors: Bradbury BD, Jick H.
Published in: Brit J Clin Pharmacol 2004;58:209-211.
Abstract 57:

DID: 57
Authors: Bradbury BD, Jick H.
Title: Brit J Clin Pharmacol 2004;58:209-211.
Reference: In vitro fertilization and childhood retinoblastoma
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Abstract:
Aims To estimate the frequency of childhood retinoblastoma among children conceived by in vitro fertilization (IVF). Methods Using the United Kingdom-based General Practice Research Database (GPRD), we identified all live births, cases of retinoblastoma and IVF procedures occurring between January 1989 and December 2001. Results We identified 0 cases of retinoblastoma among 176 children conceived by IVF (Risk = 0/176, one-sided 97.5% CI 0, 0.02) and 24 cases of retinoblastoma diagnosed...

By: Jeff | October 20, 2016

Authors: Hernan MA, Jick SS, Olek MJ, Jick H.
Published in: Neurology 2004;63:838-842.
Abstract 58:

DID: 58
Authors: Hernan MA, Jick SS, Olek MJ, Jick H.
Title: Neurology 2004;63:838-842.
Reference: Recombinant hepatitis B vaccine and the risk of multiple sclerosis: a prospective study
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Abstract:
Background: A potential link between the recombinant hepatitis B vaccine and an increased risk of multiple sclerosis (MS) has been evaluated in several studies, but some of them have substantial methodologic limitations. METHODS: The authors conducted a nested case-control study within the General Practice Research Database (GPRD) in the United Kingdom. The authors identified patients who had a first MS diagnosis recorded in the GPRD between ...

Category: Publications 2004 

Tags: Neurology 

By: Jeff | October 20, 2016

Authors: Bradbury BD, Lash TL, Kaye JA, Jick SS.
Published in: Breast Cancer Research & Treatment 2004;87:189.
Abstract 59:

DID: 59
Authors: Bradbury BD, Lash TL, Kaye JA, Jick SS.
Title: Breast Cancer Research & Treatment 2004;87:189.
Reference: Tamoxifen and cataracts: a null association
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Abstract:
Background: Previous studies have reported an increased risk of cataract for breast cancer patients treated with tamoxifen. We assessed whether breast cancer patients treated with tamoxifen were at increased risk of developing cataracts compared to women not prescribed tamoxifen. METHODS: We used a nested, matched case-control study design and data collected in the General Practice Research Database. We identified all women 30-79 ...

By: Jeff | October 20, 2016

Authors: Kaye JA, Jick H.
Published in: N Engl J Med 2004;350:2722-3.

Category: Publications 2004 

Tags: N Engl J Med 

By: Jeff | October 20, 2016

Authors: Schlienger RG, Kraenzlin ME, Jick S, Meier CR.
Published in: JAMA 2004;292:1326-1332.
Abstract 61:

DID: 61
Authors: Schlienger RG, Kraenzlin ME, Jick S, Meier CR.
Title: JAMA 2004;292:1326-1332.
Reference: Use of beta-blockers and risk of fractures
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Abstract:
Context Animal studies suggest that the -blocker propranolol increases bone formation, but data on whether use of -blockers (with or without concomitant use of thiazide diuretics) is associated with reduced fracture risk in humans are limited. Objective To determine whether use of -blockers alone or in combination with thiazides is associated with a decreased risk of fracture in adults. Design, Setting, and Participants Case-control analysis using the UK General Practice...

Category: Publications 2004 

Tags: JAMA 

By: Jeff | October 20, 2016

Authors: Schlienger RG, Fisher LM, Jick H. Meier CR. 
Published in: Drug Safety 2004;27:1157-1165.
Abstract 61:

DID: 61
Authors: Schlienger RG, Kraenzlin ME, Jick S, Meier CR.
Title: JAMA 2004;292:1326-1332.
Reference: Use of beta-blockers and risk of fractures
No direct link.

Abstract:
Context Animal studies suggest that the -blocker propranolol increases bone formation, but data on whether use of -blockers (with or without concomitant use of thiazide diuretics) is associated with reduced fracture risk in humans are limited. Objective To determine whether use of -blockers alone or in combination with thiazides is associated with a decreased risk of fracture in adults. Design, Setting, and Participants Case-control analysis using the UK General Prac...

Category: Publications 2004 

Tags: drug Safety 

By: Jeff | August 11, 2016

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Authors: Fischer LM, Schlienger RG, Matter C, Jick H, Meier CR.
Published in: Arch Int Med 2004;164:2472-6.
Abstract 63:

DID: 63
Authors: Fischer LM, Schlienger RG, Matter C, Jick H, Meier CR.
Title: Arch Int Med 2004;164:2472-6.
Reference: Discontinuation of use of nonsteroidal anti-inflammatory drug therapy and risk of acute myocardial infarction
No direct link.

Abstract:
Background Systemic inflammation has been shown to be associated with an increased risk of acute myocardial infarction (AMI). However, the effect of the use of nonsteroidal anti-inflammatory drugs (NSAIDs) on the risk of AMI has not yet been well defined. We therefore studied the risk of AMI during NSAID exposure and after the cessation of NSAID therapy. ...

By: Jeff | August 11, 2016

Authors: Kaye JA, Jick H.
Published in: Injury Prev 2004;10:368-374.
Abstract 64:

DID: 64
Authors: Kaye JA, Jick H.
Title: Injury Prev 2004;10:368-374.
Reference: Epidemiology of lower limb fractures in general practice in the United Kingdom
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Abstract:
Study objective: To estimate the incidence of lower limb fractures in the United Kingdom and assess the relative importance of various risk factors for lower limb fractures. Design: Cohort analysis and matched case-control study. Setting: General practices contributing information to the General Practice Research Database. Subjects: Individuals registered with these general practices who were at risk for a first time lower limb fracture from 1 January1990 to 31 December 2001. Main outco...

Category: Publications 2004 

Tags: injury Prev 

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