Boston Collaborative Drug Surveillance Program

By: Jeff | October 25, 2016

Authors: Jick H, Chamberlin DP, Hagberg KW. 
Published in: Epidemiology 2009;20:656-61.

Abstract 109:

DID: 109
Authors: Jick H, Chamberlin DP, Hagberg KW.
Title: Epidemiology 2009;20:656-61.
Reference: The origin and spread of a mumps epidemic – United Kingdom, 2003-2006
No direct link.

Abstract:
Background: The United Kingdom (UK) underwent a massive epidemic of mumps from 2003 through 2006. The origin and spread was mapped in 350 general practices that used office computers to contribute comprehensive medical information on approximately 3 million patients to the General Practice Research Database (GPRD). METHODS: The continuous 3-month cumulative incidence of mumps (2003-2006) was estimated by dividing the number of diagnosed cases of mumps each ...

Category: Publications 2009 

Tags: Epidemiology 

By: Jeff | October 25, 2016

Authors: Jick H, Hagberg KW, Egger P.  
Published in: Pharmacotherapy 2009;165-6.
Abstract 108:

DID: 108
Authors: Jick H, Hagberg KW, Egger P.
Title: Pharmacotherapy 2009;165-6.
Reference: Rate of suicide in patients taking montelukast.
No direct link.

Abstract:
Study Objective. To estimate the rate of suicide in patients taking montelukast. Design. Population-based cohort study. Data Source. United Kingdom General Practice Research Database. Patients. A total of 23,500 patients who had received at least one prescription for montelukast in the cumulative data from February 1998–March 2007. Measurements and Main Results. Rate of suicide was to be calculated as number of suicides divided by person-time at risk. Person-time of montelukast exposure was ...

By: Jeff | October 25, 2016

Authors: Brauchli YB, Jick SS, Miret M, Meier CR.
Published in: Brit J Dermatol 2009;160:1048-56.
Abstract 107:

DID: 107
Authors: Brauchli YB, Jick SS, Miret M, Meier CR.
Title: Brit J Dermatol 2009;160:1048-56.
Reference: Psoriasis and risk of incident myocardial infarction, stroke, or transient ischemic attack: an inception cohort with a nested case-control analysis
No direct link.

Abstract:
Background: Systemic inflammation may increase the risk for cardiovascular diseases in patients with psoriasis, but data on this risk in patients with early psoriasis are scarce. ObjectiveS: To assess and compare the risk of developing incident myocardial infarction (MI), stroke or transient ischaemic attack (TIA) between an inception cohort of patients with p...

By: Jeff | October 25, 2016

Authors: Jick SS, Hagberg KW, Kaye JA, Jick H.
Published in: Obstet Gynecol 2009;113:74-80.
Abstract 106:
Objective: To investigate the relation of various estrogen-containing hormone therapies to the risk of breast cancer, emphasizing the use of the combination of estrogen and testosterone. METHODS: Using information from a large U.S.-based claims database, we conducted a case-control study in women aged 50 to 64 years who had a first-time diagnosis of breast cancer to estimate the effect in users of conjugated estrogen alone, conjugated estrogen plus progestin, esterified estrogen with methyltestosterone, or esterified estrogen with methyltestosterone plus progestin, compared with nonusers. Four controls were matched to each case on year of ...

By: Jeff | October 25, 2016

Authors: Jick H. 
Published in: J Roy Soc Med 2009;102:160-4.

Category: Publications 2009 

Tags: J Roy Soc Med 

By: Jeff | October 25, 2016

Authors: Jick SS, Choi H, Li L, McInnes I, Sattar N.
Published in: Ann Rheum Dis 2009;68:546-51.
Link: No Link
Abstract 104:

Objective: To evaluate whether statins are associated with a protective effect on the development of rheumatoid arthritis (RA).

Methods: A nested case–control study was conducted using data from the General Practice Research Database. A study population consisting of three groups of subjects aged 40–89 years was identified: (1) patients exposed to a statin or other lipid-lowering agent (LLA); (2) patients with a diagnosis of hyperlipidaemia in the absence of lipid-lowering drug treatment and (3) a random sample of 25 000 individuals with no diagnosis of hyperlipidaemia nor a prescription for a LLA. From this population inc...

Category: Publications 2009 

Tags: Ann Rheum Dis 

By: Jeff | October 25, 2016

Authors: Schoonen WM, Kucera G, Coalson J, Li L, Rutstein M, Mowat F, Fryzek J, Kaye JA.
Published in: Br J Haematol 2009;145:235-244.
Abstract 122:

DID: 122
Authors: Schoonen WM, Kucera G, Coalson J, Li L, Rutstein M, Mowat F, Fryzek J, Kaye JA.
Title: Br J Haematol 2009;145:235-244.
Reference: Epidemiology of immune thrombocytopenic purpura in the General Practice Research Database
No direct link.

Abstract:
The epidemiology of immune thrombocytopenic purpura (ITP) is not well-characterised in the general population. This study described the incidence and survival of ITP using the UK population-based General Practice Research Database (GPRD). ITP patients first diagnosed in 1990-2005 were identified in the GPRD. Overall incidence rates (per 100,000...

Category: Publications 2009 

Tags: Br J Haematol 

By: Jeff | October 25, 2016

Authors: Schneider C, Jick SS, Meier CR.
Published in: Climacteric 2009;12:445-53.
Abstract 119:

DID: 119
Authors: Schneider C, Jick SS, Meier CR.
Title: Climacteric 2009;12:445-53.
Reference: Risk of cardiovascular outcomes in users of estradiol/dydrogesterone or other HRT preparations
No direct link.

Abstract:
Background: Use of postmenopausal hormone replacement therapy (HRT) used to be promoted to reduce the risk of ischemic cardiovascular diseases, a concept which has been challenged by results of the large Women’s Health Initiative trial in users of estrogen and progestin. It is postulated that the type of progestin used in HRT affects the cardiovascular risk. METHODS: We used the UK-based General Practice Research Database to conduct a follow...

Category: Publications 2009 

Tags: Climacteric 

By: Jeff | October 24, 2016

Authors: Schneider C, Jick SS, Meier CR.
Published in: Climacteric 2009;12:514-24.
Abstract 118:

DID: 118
Authors: Schneider C, Jick SS, Meier CR.
Title: Climacteric 2009;12:514-24.
Reference: Risk of gynecological cancers in users of estradiol/dydrogesterone or other HRT preparations
No direct link.

Abstract:
ObjectiveS: Use of postmenopausal hormone replacement therapy (HRT) has been associated with an elevated risk of gynecological cancers. There is evidence that the effect differs with the type of hormone used. Dydrogesterone is pharmacologically very similar to progesterone. METHODS: We used the UK-based General Practice Research Database (GPRD) to conduct a follow-up study with a nested case-control analysis. We assessed and compared the risk ...

Category: Publications 2009 

Tags: Climacteric 

By: Jeff | October 24, 2016

Authors: Alonso A, Logroscino G, Jick SS, Hernan MA.
Published in: Eur J Neurol 2009;16:745-51.
Abstract 117:

DID: 117
Authors: Alonso A, Logroscino G, Jick SS, Hernan MA.
Title: Eur J Neurol 2009;16:745-51.
Reference: Incidence and lifetime risk of motor neuron disease in the United Kingdom: a population-based study
No direct link.

Abstract:
Background AND Purpose: To estimate the incidence and lifetime risk of motor neuron disease (MND) in a population-based sample in the United Kingdom. METHODS: We identified new cases of MND during the period 1990-2005 in the General Practice Research Database, which includes clinical information from more than 3 million Britons enrolled with selected general practitioners. Individuals with a first medical diagn...

Category: Publications 2009 

Tags: Eur J Neurol 

By: Jeff | October 24, 2016

Brauchli YB, Jick SS, Curtin F, Meier CR.
J Clin Psychopharmacol 2009;29:134-40.
Abstract 116:

DID: 116
Authors: Brauchli YB, Jick SS, Curtin F, Meier CR.
Title: J Clin Psychopharmacol 2009;29:134-40.
Reference: Lithium, antipsychotics, and risk of psoriasis
No direct link.

Abstract:
Background: Observations in controlled trials and case reports have linked lithium exposure to induction or exacerbation of psoriasis. A causal relationship between lithium exposure and incident psoriasis has been questioned, and observational studies are lacking. METHODS: We conducted a case-control analysis using the United Kingdom-based General Practice Research Database to study the association between the use of lithium or antipsychotics and the risk of developing ...

By: Jeff | October 24, 2016

Authors: Brauchli YB, Jick SS, Miret M, Meier CR. 
Published in: J Investig Dermatol 2009;129:2604-12.
Abstract 115:

DID: 115
Authors: Brauchli YB, Jick SS, Miret M, Meier CR.
Title: J Investig Dermatol 2009;129:2604-12.
Reference: Psoriasis and risk of incident cancer: an inception cohort study with a nested case-control analysis
No direct link.

Abstract:
Psoriasis has been associated with lymphohematopoietic and solid cancers; however, reports have been inconsistent. Cancer incidence was compared between psoriasis and psoriasis-free patients, and the roles of psoriasis duration and treatment were explored in this observational study using the UK General Practice Research Database. Among 67,761 patients, 1,703 patients had incident cancer; of whom ...

By: Jeff | October 24, 2016

Authors: Bodmer M, Brauchli YB, Krahenbuhl S, Jick SS, Meier CR.
Published in: JAMA 2009;302:2001-7.
Abstract 114:

DID: 114
Authors: Bodmer M, Brauchli YB, Krahenbuhl S, Jick SS, Meier CR.
Title: JAMA 2009;302:2001-7.
Reference: Statin use and risk of gallstone disease followed by cholecystectomy
No direct link.

Abstract:
Context: Gallstone disease is a leading cause of morbidity in western countries and carries a high economic burden. Statins decrease hepatic cholesterol biosynthesis and may therefore lower the risk of cholesterol gallstones by reducing the cholesterol concentration in the bile. Data on this association in humans are scarce. Objective: To study the association between the use of statins, fibrates, or other lipid-lowering agents and...

Category: Publications 2009 

Tags: JAMA 

By: Jeff | October 24, 2016

Authors: Osman M, Black C, Jick S, Hannaford PC. 
Published in: Paediatric and Perinatal Epidemiology 2009;23:567-73.
Abstract 113:

DID: 113
Authors: Osman M, Black C, Jick S, Hannaford PC.
Title: Paediatric and Perinatal Epidemiology 2009;23:567-73.
Reference: Previous maternal oral contraception and the risk among subsequent offspring of asthma diagnosis in early childhood
No direct link.

Abstract:
Previous maternal use of the oral contraceptive pill (OCP) has been linked with asthma in subsequent offspring and has been implicated in the increased prevalence of childhood asthma in recent decades. We conducted a matched case-control study to test the hypothesis that maternal OCP used close to conception is associated with asthma in the offspring, p...

By: Jeff | October 24, 2016

Authors: Li L, Jick H, Jick SS.  
Published in: Brit J Clin Pharmacol 2009;68:269-70. 
Abstract 111:

DID: 111
Authors: Li L, Jick H, Jick SS.
Title: Brit J Clin Pharmacol 2009;68:269-70.
Reference: Updated study on the risk of cholestatic liver disease and flucloxacillin (letter).
No direct link.

Abstract:
112 Epidemiology of immune thrombocytopenic purpura in the General Practice Research Database

By: Jeff | October 24, 2016

Authors: Jick SS, Hagberg KW, Kaye JA, Jick H.
Published in: Contraception 2009;80:142-151.
Abstract 110:

DID: 110
Authors: Jick SS, Hagberg KW, Kaye JA, Jick H.
Title: Contraception 2009;80:142-151.
Reference: The risk of unintended pregnancies in users of the contraceptive patch compared to users of oral contraceptives in the U.K. General Practice Research Database
No direct link.

Abstract:
Background: The transdermal contraceptive patch EVRA has been marketed since 2002 as an alternative to oral contraceptives (OCs), but large follow-up studies of effectiveness are lacking. STUDY DESIGN: We used a cohort plus a nested case-control study to estimate rates and hazard ratios of unintended pregnancy among users of different hormonal contraceptives (H...

Category: Publications 2009 

Tags: Contraception 

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