Authors: Jick SS, Choi H, Li L, McInnes I, Sattar N.
Published in: Ann Rheum Dis 2009;68:546-51.
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Objective: To evaluate whether statins are associated with a protective effect on the development of rheumatoid arthritis (RA).
Methods: A nested case–control study was conducted using data from the General Practice Research Database. A study population consisting of three groups of subjects aged 40–89 years was identified: (1) patients exposed to a statin or other lipid-lowering agent (LLA); (2) patients with a diagnosis of hyperlipidaemia in the absence of lipid-lowering drug treatment and (3) a random sample of 25 000 individuals with no diagnosis of hyperlipidaemia nor a prescription for a LLA. From this population inc...