Boston Collaborative Drug Surveillance Program

By: Jeff | October 20, 2016

Authors: Peng MM, Jick H.
Published in: Arch Intern Med 2004;164:317-319
Abstract 49:

DID: 49
Authors: Peng MM, Jick H.
Title: Arch Intern Med 2004;164:317-319
Reference: A population-based study of the incidence, cause, and severity of anaphylaxis in the United Kingdom
No direct link.

Background: Anaphylaxis is an acute and potentially fatal systemic reaction usually caused by mast cell-mediated release of histamine. Symptoms can vary in onset, appearance and severity. Some common symptoms include weakness, dizziness, flushing, angioedema, urticaria, nasal congestion and sneezing. Severe symptoms include upper respiratory tract obstruction, hypotension, vascular collapse associated with angioedema and urticaria, gastrointestinal distress,...

By: Jeff | August 11, 2016

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Authors: Fischer LM, Schlienger RG, Matter C, Jick H, Meier CR.
Published in: Arch Int Med 2004;164:2472-6.
Abstract 63:

DID: 63
Authors: Fischer LM, Schlienger RG, Matter C, Jick H, Meier CR.
Title: Arch Int Med 2004;164:2472-6.
Reference: Discontinuation of use of nonsteroidal anti-inflammatory drug therapy and risk of acute myocardial infarction
No direct link.

Background Systemic inflammation has been shown to be associated with an increased risk of acute myocardial infarction (AMI). However, the effect of the use of nonsteroidal anti-inflammatory drugs (NSAIDs) on the risk of AMI has not yet been well defined. We therefore studied the risk of AMI during NSAID exposure and after the cessation of NSAID therapy. ...

By: Jeff | August 11, 2016

Authors: Schlienger RG, Haefeli WE, Jick H, Meier CR.
Published in: Arch Intern Med 2001;161:2021-2026
Abstract 23:

DID: 23
Authors: Schlienger RG, Haefeli WE, Jick H, Meier CR.
Title: Arch Intern Med 2001;161:2021-2026
Reference: Risk of cataract in patients treated with statins
No direct link.

Background: Studies in dogs showed that some hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) are associated with cataract when administered in excessive doses. Clinical safety data of statins regarding cataract development in humans have been of limited value so far. Objective: To determine whether long-term use of statins is associated with an increased risk of cataract. Methods: We conducted a case-control analysis using data from...




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