Authors: Schlienger RG, Fisher LM, Jick H. Meier CR.
Published in: Drug Safety 2004;27:1157-1165.
Authors: Schlienger RG, Kraenzlin ME, Jick S, Meier CR.
Title: JAMA 2004;292:1326-1332.
Reference: Use of beta-blockers and risk of fractures
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Context Animal studies suggest that the -blocker propranolol increases bone formation, but data on whether use of -blockers (with or without concomitant use of thiazide diuretics) is associated with reduced fracture risk in humans are limited. Objective To determine whether use of -blockers alone or in combination with thiazides is associated with a decreased risk of fracture in adults. Design, Setting, and Participants Case-control analysis using the UK General Prac...